- Agri-Education, Inc.
 - Provides educational software and curriculum in agriculture. - Biodisc, Inc.
- Sells software for teaching biology, genetics, anthropology, and more. Also sells photomicrographs on CD-ROM, laserdisc, Photo CD, and transparencies.
- Biopac Systems
- Sells the Biopac Student Lab, hardware and software for teaching physiology. Also sells a system for data acquisition and analysis for research.
- Brainviews, Ltd.
- Creators and publishers of CD-ROM courseware for the study of brain and behaviour.
- Ceres Software Corporation
- Designers of educational activities for high school students in the areas of physics, chemistry, physical science, earth and space science, and computer science.
- CyberEd
- Develops interactive biology courseware products.
- CyberLearning Collection
- Software on biology, the environment, computer music, coral reef and salmon ecology.
- Educo International, Inc.
- Sells multimedia software for teaching and testing math, biology, and chemistry. Textbooks and lecture notes complement the software programme.
- Eighteen Software
- Develops programmes which simulate mineral exploration campaigns in order to teach geology for high school, college, and professional levels.
- Emaginings
- Multimedia reference CD-ROMS about earth sciences including volcanoes, hurricanes, earthquakes, tornadoes, floods, and global warming.
- Encore Software
- Offers games and education software.
- ETCAI Products
- Develops software which teaches electricity, electronics, and avionics.
- Exploration In Education
- Series of interactive, downloadable images and text on exploring space. Also available on CD-ROM.
- Falcon Software, Inc
- Publishers of educational software in the areas of chemistry, electronics, and environmental science. Specialising in laboratory simulations.
 Focus Educational Software
- Offers CD-ROMs for physics, science, and design technology.- Interactive Learning Inc.
- Offers educational and interactive science tutors for biology, chemistry, and physics for high school and college students.
- Intuitive Systems, Inc.
- Maker of VirtualUnknown Microbiology, a PC-based microbiology laboratory simulation product.
- Learning in Motion
- Creators of math and science software for K-12 education.
- Learning Quest, Inc.
- Develops science software for the classroom. Also offers curriculum, assessment, and technology integration workshops.
- Planet Earth Science
- Offers virtual research expeditions in which students use satellite observations of the Earth and data from climate models to study the Earth as a system of interacting components.
- ScienceMedia
- Publishes interactive multi-media software for the biological and chemical sciences at the university/college and high school levels.
- Scienceworks Inc.
- Software for dissections, weather, chemistry, and more.
- Seeds Software
- Publishes software for exploring aeroplane design, egg-dropping experiments, and science methods.
- Tangent Scientific
- Producer and supplier of biology, chemistry, physics, earth and space, anatomy and physiology, and environmental educational software.
- Ventura Educational Systems
- Publishes math and science learning software. Also creates clip art files for teachers.
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