- Under Secretary for Political Affairs
 - Includes remarks from the current Under Secretary and information about the integration of political, economic, global, and security issues into the United States' bilateral relationships. - Bureau of African Affairs (2)
- Bureau of East Asian and Pacific Affairs
- Includes regional topics and fact sheets, press releases, updates, and more covering U.S. foreign policy and U.S. relations with the countries in the Asia-Pacific region.
- Bureau of European and Eurasian Affairs
- Features regional topics, information on U.S. assistance to Europe and Eurasia, press releases, updates, and more.
- Bureau of Near Eastern Affairs
- Deals with U.S. foreign policy and diplomatic relations with Algeria, Bahrain, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Qatar, Saudi Arabia, Syria, Tunisia, United Arab Emirates, and Yemen.
- Bureau of South Asian Affairs
- Deals with U.S. foreign policy and U.S. relations with the countries of Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka.
- Bureau of Western Hemisphere Affairs
- Features regional topics, press releases, updates, and more on the bureau's interests in Canada, Mexico, Central and South America, and the Caribbean.
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