- Aim High
 - Reporting items of interest relating to Down Syndrome and providing a forum for families dealing with it. - Breastfeeding a Baby With Down Syndrome
- Includes benefits, information, support groups, and more.
- Down Syndrome
- Offers information including FAQ, medical articles, links to organisations and support groups, event calendar, and more.
- Down Syndrome Information Network
- Down Syndrome Quarterly
- Interdisciplinary journal devoted to advancing the state of knowledge on Down Syndrome, covering all areas of medical, behavioural, and social scientific research.
- Down Syndrome: For New Parents
- Provides information and resources.
- Down Syndrome: Health Issues
- Collection of medical essays and information.
- Downi Creations
- Offers collectible dolls created with the realistic features of children with Down Syndrome.
- DownsCity
- Information services, national events, marketplace and personalities sections.
- DownsNet
- Provides web space, access, and support to improve the information products, and services available to the Down Syndrome Community.
- Fundacio Catalana Sindrome de Down
- Nonprofit organisation offering resources, advice, research information, and more on Down Syndrome. In Spanish and English.
- Mosaic Down Syndrome on the Web
- Includes FAQ, message board, personal stories, and more.
- Pathfinder Village
- Village specialising in Down Syndrome.
- Riverbend Down Syndrome Parent Support Group
- Provides support and information to parents of children with Down syndrome in Southwestern Illinois.
- Targeted Nutritional Intervention - TNI
- Therapy for children with Down Syndrome which is designed to make them healthier and improve cognitive performance.
- Uno Mas! Down Syndrome Online
- Offers information, pictures, calendar of events, contests and more.
- Wikipedia: Down Syndrome
- Article about Down Syndrome, a genetic disorder caused by the presence of all or part of an extra 21st chromosome.
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