- Hancock Jaffe Laboratories, Inc.
 - Irvine - Develops bioprosthetic vascular grafts for patients with vascular, cardiovascular, and end-stage renal disease. - Hungry Heart
- Laguna Niguel - Programme to help clients break out of the diet/binge cycle and lose weight naturally and permanently.
- Sobobamedspa.com
- Costa Mesa - Offers weight loss programmes in Orange county, Costa Mesa, and Laguna Hills.
- Wakunaga of America Co., Ltd.
- Mission Viejo - Offers kyolic garlic supplements.
- Whip Wetless Anti-Sweat Lotion
- Los Alamitos - Controls sweating for people with hyperhidrosis.
- Yummi Bears
- San Clemente - Children's supplement nutritional manufacturer of gummy bear vitamins.
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