- Sluggy Freelance
 - Features the adventures of two young men, one woman, and a rabbit. - Sinfest
- Comic strip featuring Slick, Monique, God, and other characters by Tatsuya Ishida.
- Something Positive
- A comic strip by R.K. Milholland about two good friends, a girl named Aubrey, and a jerk named Davan.
- Scary Go Round
- John Allison's webcomic updates daily.
- Schlock Mercenary
- Online comic by Howard Tayler - plotting to take over the world since 1998.
- Sexy Losers
- Also published bi-monthly in A-G Comics.
- Softer World, A
- Photographs and text make an offbeat combination in this weekly art comic.
- Spamusement!
- Poorly drawn cartoons inspired by actual spam subject lines.
- Sherman's Lagoon
- Offers a daily cartoon set in a tropical lagoon, a collection of classics, and a free screen saver for Windows.
- Slow Wave
- Collective dream diary authored by different people from around the world and drawn by Jesse Reklaw.
- Sam and Fuzzy
- Comic strip by Sam Logan updated Mondays, Wednesdays, and Fridays.
- Superosity
- Daily colour humour comic strip about a guy in a cape, a cocker spaniel dog, a teenager, a genius board, and the apartment they share.
- Sparkling Generation
- The adventures of androgynous teenager Valkyrie Yuuki.
- Sore Thumbs
- Political gaming Manga-type comics by Owen Gieni and Chris Crosby.
- Steve and Bluey
- Official site for Steven Fischer's cartoon comedy team, Steve and Bluey.
- Striptease
- The comic strip about a comic book.
- Savage Chickens
- Chicken cartoons on sticky notes by Doug Savage.
- Stone Soup (2)
- SideStream, The
- Proclaiming the good news by offering free Christian cartoons, clip art, graphics, and more.
- Small Stories
- Comics to make love to as drawn by Derek Kirk.
- Stuff Sucks
- A weekly online comic by Liz Greenfield about life, love, and rock.
- Space Moose
- Enjoy the irreverent antics of an antlered nihilist and his motley band of vulgarians.
- Skinny Panda
- By Phil Cho.
- Strangerhood, The
- Online animation series from the creators of Red Vs. Blue made using the Sims 2 video game.
 Sheldon
- About a ten-year old genius, his talking duck, and their multi-billion dollar Internet company, by Dave Kellett.- Sneaky and Creepy
- Adventurous, mischievous roaches with an attitude with eCards, comic strips and more.
- Scary Bear
- Daily strip by Jason Pultz.
- Spells & Whistles
- Fantasy adventure updated once a week by Tauhid Bondia.
- Scott's Mind
- Weekly cartoons and animation.
- Soft Targets (1)
- smallgreY
- A smallgreY alien, a sexy Venutian, a tormented Martian, 3 cats, the Lorang and a 'primitive' man live their lives in Cydonia, Mars.
- Shoe (2)
- Scrambled Pancakes
- Daily comic strip by Rick Koshko.
- Spade-Men, The
- Comic featuring a group of friends turned unlikely superheroes.
- Skirting Danger
- Comic strip starring Courtney Brightland, fashion student with big dreams.
- Speed Bump
- Sylvia
- Official site for the comic strip by Nicole Hollander.
- Spy vs Spy (4)
- Laugh with Spy vs Spy, the MAD Magazine comic strip featuring two protagonists. Sites provide cartoons, articles, and links related to the Black and White spies created by Antonio Prohias.
- Stile Sux
- Discover what it's like to be the webmaster of one of the most disgusting, immoral, and perverted web sites on the Internet.
- Stupidmonsters
- Sketchbook comics by Gary Northfield with characters including monsters, dogs, and wasps.
- Smokey Stover
- Screwball comic created by Bill Holman featuring the foo fighting fireman and his firetruck, the Foomobile. Words and phrases from the strip include Foo, Notary Sojac, and 1506 Nix Nix.
- Sick Nick
- Daily cartoons by Nikahang Kowsar about a journalist called Nick.
- Schizophrenics
- Online comic about what happens if fan-created characters get out of hand. Featuring vampires, Saiyans, and Jedi.
- Steverino
- Join Steverino and friends as they ponder life and love while dealing with the daily events we all encounter.
- Snap The Punk Turtle
- The humorous meanderings of a wacky guy named SuperChris and his friends. New FULL Colour strips every Tuesday!
- Scrubs
- Online comic strip detailing the life and times of two Chinese-American best friends.
- Smilin' Jack
- Adventure strip that ran from 1933 to 1973 featuring a dashing aviator.
- Strange Snow
- Autobiographical bi-weekly comic. Site includes a section about the comic Strange Snow, as well as a bio of the artist, and links to other online comics.
- Staggering Heights
- By Joe Forkan.
- Safari Sam
- Adventures of a kid, his mutant elephant, and a Canadian prescription drug lord, among others.
- Super Puppies From Outer Space
- Ongoing adventure suitable for the whole family.
- Sev Trek
- Join the crew as they politically correctly go where no one has politically correctly gone before!
- Snootle
- Comic strip features Snootle, Prim, Rose, Bud, Tansy, and other characters created by Tia Petty.
- SpenComics
- Comic about what its like to go through high school, with your head on fire.
- Safe Havens
- Steve Roper and Mike Nomad
- Sam & Silo
- Slylock Fox and Comics for Kids (2)
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