- National Down Syndrome Society (2)
- National Association for Down Syndrome (NADS)
 - News, resources, and scientific information related to down syndrome from NADS, a not-for-profit organisation serving people in the Chicago metropolitan area. - National Down Syndrome Congress
- Creating a national climate in which all persons will recognise and embrace the value and dignity of persons with Down syndrome.
- Canadian Down Syndrome Society
- Information on Down syndrome and CDSS, a list of parent support groups across Canada, resources and links to other sites.
 Down's Syndrome Medical Interest Group
- Promotes interest in the specialist medical management of Down's syndrome.- Down's Syndrome Research Foundation Ltd
- Initiates medical research projects to improve the outcome for children with trisomy 21.
- Down syndrome Association of Cincinnati
 Down Syndrome Ireland
- Finding ways to improve the lives of those with Down Syndrome and help them reach their full potential.- UPSIDE! Down Syndrome Society
- Group of individuals, families, and friends involved with Down Syndrome.
- Colorado Springs Down Syndrome Association (CSDSA)
- Nonprofit organisation, established as a family interaction group.
- Down Syndrome Association of Orange County
- Nonprofit organisation formed by parents to provide support and information to families in Orange County affected by Down syndrome.
- Indiana Down Syndrome Foundation
- An organisation dedicated to raising awareness for people with this disorder and to provide information and support.
- Down Syndrome Association Los Angeles
- Aims to enhance the welfare of people with Down Syndrome by development of education, counselling, employment, and recreational programmes.
- Down Syndrome Association of Wisconsin (DSAW)
- Offers event calendar, newsletter, photos, links and information.
- Down Syndrome Association of Atlanta
- Advocates ongoing research and public awareness. Also provides support for families and friends.
- Karen Gaffney Foundation (Down Syndrome Education)
- Championing the journey to full inclusion for people with Down Syndrom in schools, the workplace and communities.
- Down Syndrome Association, Singapore
- Nonprofit organisation serving individuals with Down syndrome and their families.
- Down Syndrome International (DSI)
- Federation of international organisations and individuals committed to ensuring the quality of life for people with Down Syndrome. Organises the annual World Down Syndrome Congress events.
- Scottish Down's Syndrome Association
- Works to improve the quality of life for everyone who has Down's syndrome in Scotland.
- Down Syndrome of South Australia Inc
- Outlines information about available services, education, and resources.
- Center for Research and Treatment of Down Syndrome
- Dedicated to improving life for people with Down Syndrome.
- Down Syndrome of Louisville
- Provides information and resources.
- Trisomy 21 Foundation of Northern New York
- Mission is to improve the quality of life of adults and children with Down's Syndrome through education, funding, and research.
- Annie Forts UP Syndrome Fund
- Nonprofit fund assisting in education and assistance to individuals with Down Syndrome and supporting the study of treatment and rehabilitation.
- Massachusetts Down Syndrome Congress
- Definition, resources, education, early intervention, and financial matters.
- Down's Syndrome Association UK@
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